Table 1

Dose-dependent inhibition of Aβ_1–40 monomer aggregation and fibril growth in the presence of BSA ^a

Reaction

Monomer Aggregation ^c

Fibril Growth ^d

(BSA:Aβ^b)

Lag Time

(fold increase)

Plateau

(% reduction)

Growth Rate

(% inhibition)

1:4

---

---

49 ± 11 *

1:1

1.9 ± 0.4

6 ± 6

61 ± 17 *

2:1

2.4 ± 0.6

34 ± 18

---

4:1

> 7 *

97 ± 2 *

---

5:1

---

---

80 ± 11 *

^a Parameters are expressed as mean ± SE, n = 3.

^b Aβ_1–40 fibril concentrations are expressed in monomer units.

^c Monomer aggregation was measured as in Figure 1.

^d Fibril growth was measured as in Figure 2.

* p < 0.05 compared to control.

Reyes Barcelo et al. Journal of Biological Engineering 2009 3:5   doi:10.1186/1754-1611-3-5