Figure 4.

Effect of BSA inhibition of Aβ_1–40 monomer aggregation on aggregate size distribution. Aβ_1–40 monomer aggregations were performed as in Figure 1 for 20 μM Aβ_1–40 monomer in the presence of 0 μM (panel B, control), 40 μM (panel C), or 80 μM (panel D) BSA. In addition, 80 μM BSA was subjected to aggregation conditions in the absence of Aβ_1–40 monomer (panel A). DLS was employed to determine R_H distributions. Results are presented as intensity-weighted histograms derived from data regularization with Dynamics Software (Wyatt Technology). Results are representative of two independent experiments.